The activity of cytochrome P450 CYP2B in rat liver during neuroleptic treatment.
Authors: Haduch A, W#xF3;jcikowski J, Daniel WA
The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the activity of rat CYP2B measured as a rate of 16beta-hydroxylation of testosterone. The reaction was studied in control liver microsomes in the presence of neuroleptics, as well as in microsomes of rats treated intraperitoneally for one day or two weeks (twice a day) with pharmacological doses (mg/kg) of the drugs (promazine, levomepromazine, thioridazine and perazine, 10 each; chlorpromazine 3; haloperidol 0.3; risperidone 0.1; sertindole 0.05), in the absence of the neuroleptics in vitro. ome of the neuroleptics added in vitro to control liver microsomes decreased the activity of CYP2B. The obtained K(i) values indicated that thiorid...div id=medwormpbiMedWorm Message:/i/b Find the best a href=http://www.januarysales.org/ target=_blankJanuary Sales/a in the UK./p/div
Avoid the afternoon stress-eating binge
That foods can soothe, reduce anxiety and boost your mood is well known to anyone who has kept a vise grip on a pint of Chunky Monkey at midnight or dived into the deep end of a party pack of chips at the end of a day gone awry. (Source: CNN.com - Health)
